Endocrine Abstracts

Central obesity and insulin resistance are more prevalent in women with PCOS, affecting both normal weight and obese subjects. The metabolic effects of insulin are partially dependent on the amount of lean mass and insulin resistance seems to selectively affect the metabolic, but not the mitogenic, actions of insulin. Therefore, this age-matched case-control study assessed total and segmental lean muscle mass in classic or ovulatory polycystic ovary syndrome (PCOS) patients an...

An association of the single nucleotide polymorphism (SNP) in the promoter gene that codify for 17b-HSD5 enzyme (71A>G) with polycystic ovary syndrome (PCOS) has been suggested in previous studies. Given the role of 17b-HSD5 in androgenic metabolism producing testosterone from precursors, the aim of this study was to assess whether non-obese PCOS women with the variant allele G have different response on hirsutism and on hormonal and metabolic variables to oral contracepti...